thyroglobulin test

Thyroglobulin (Tg) is a kind of glycoprotein homodimer primarily produced by the thyroid gland of our body. This basically acts as a substrate, aiding the synthesis of thyroxine and triiodothyronine. It also helps the storage of the iodine and thyroid hormone in inactive forms. The hormone is secreted from the endoplasmic reticulum, and subsequently to the thyroxine biosynthesis, in the follicular lumen of the body. Mutation in this genes cause thyroid dyshormonogenesis, which is manifested in the form goitre, and are related to moderate to severe congenital hypothyroidism. 

Thyroglobulin is a hormone that is produced by all individuals, and normally its concentration in blood is quite low. Thyroglobulin concentration increases in both benign and malignant conditions. So, it is an indicator of any thyroid dysfunction as well as an indicator of a tumour which is a parameter used to constantly monitor patients with thyroid papillary and follicular cancer after its diagnosis.

The normal thyroglobulin range in people without thyroglobulin antibody (TgAb) should ideally be 3-40 ng/mL in countries where there is adequate iodine intake. In approximately 8% of the general population, thyroglobulin values are usually less than 10 ng/mL

• fatigue

• unexplained weight gain

• constipation

• dry skin

• goitre

The thyroglobulin levels monitor the treatment of thyroid cancer and detect its recurrence. The thyroglobulin test also helps determine the cause of hyperthyroidism and hypothyroidism.

The thyroglobulin levels are checked before and after the completion of treatment for thyroid cancer, radioactive iodine therapy, and ideally at regular intervals. It is sometimes paired with other thyroid tests to test for certain disorders.

The thyroglobulin test is a blood test. So, the sample blood requires is usually drawn from the veins of one's arm.

Usually, no preparation is required before the thyroglobulin test. However, at certain times, depending on the method of test, some dietary supplements such as multivitamins should not be taken at least 12 hours before the test is done to avoid any kind of interference in the test.

The thyroglobilun test cost in India usually ranges from Rs.700-900.

If your result is negative, that means your thyroglobulin level in blood is normal. This indicates that means no antithyroglobulin antibodies are there in your blood sample. However, if you have small amounts of it in your blood, it may be a sign of the following health problems:

• thyroid cancer

• diabetes type 1

• a drastic decrease in the number of red blood cells in the body (pernicious anaemia) caused due to deficiency of multi-vitamins

• some collagen vascular disease

If the level of antithyroglobulin antibodies in your blood is quite high, it may indicate some serious autoimmune disorder, as serious as Graves’ disease or Hashimoto thyroiditis.

We as a team believe in healing at home. We would visit your home to collect blood samples, get the test done and arrange for highly qualified doctors right at your doorstep. We can ensure that you receive the best quality Healthcare Services right at home.

The thyroglobulin test is thus administered by collecting a blood sample under clinical settings to monitor the thyroglobulin levels in the blood. It is to check treatment of thyroid cancer, detect its recurrence or to examine abnormal conditions of the thyroid hormone in the blood.